Generic Lamisil side effects

The most common human fungal disease is athlete’s foot caused by 90 – 95% of dermatophyte Trichophyton rubrum. The share of this mycosis basic labor losses fall in the group of infectious lesions. For this pathogen characteristic skin lesions feet, hands, body and nail plates – onychomycosis, which occur in 50 – 70% of patients.

The number of patients with onychomycosis increases every year, which is attributed to the overall aging of the population, reducing the natural immune defenses of the human body due to environmental degradation, the use of such therapies as immunosuppressants, corticosteroids, antibiotics, adverse effects of other factors for the body of endo- and exogenous nature.

Representative of a class of allylamines – chemical compounds that are included in the arsenal of the most effective treatments for tinea and, in particular, onychomycosis, is terbinafine (Lamisil), created in 1982, a group of chemists of Swiss “Sandoz” (now “Novartis”). To date Lamisil passed multilateral clinical trials and has become a practice of treating patients with mycosis in all dermatological institutions worldwide.

Lamisil is produced as both 250 and tablets of 125 mg (14 and 28 per pack ) and 1% cream containing 10 mg of terbinafine hydrochloride in 1 g product ( 15 g per tube). Active component of the drug is terbinafine – allylamine derivative (fungicidal compound of a new class). This is first drug with broad spectrum antifungal activity. It has a direct effect on the fungicidal dermatophytes, yeast and fungi both in oral and local application. The concept of the spectrum of activity includes a range of those organisms against which laboratory methods determine the minimum inhibitory concentration (MIC). In principle, a certain degree MIC results correlated with the application of the drug in clinical practice, although this should be interpreted with caution.

Low concentrations of the drug in blood plasma stored for 4 – 6 – 8 weeks after his admission. Such long-term persistence of terbinafine in the bloodstream may be one of the reasons they caused side effects. There are reports of temporary loss of taste, which however, are reversed through the 2 – 5 weeks and did not require discontinuation of therapy. Usually patients notice a discomfort in the stomach and intestines, and urticaria.

Pretty easy is to tolerate treatment of onychomycosis in elderly and senile. There are studies on safety and efficacy when administered oral treatment of onychomycosis in patients with kidney transplant recipients who are at an appropriate immunosuppressive therapy, and patients with AIDS. Contraindication to treatment of onychomycosis is hypersensitivity to terbinafine or relevant ingredients of the cream.

The side effects of generic lamisil are similar with brand : gastrointestinal disorders (nausea, abdominal pain, anorexia, delayed gastric emptying, diarrhea), headache, skin reactions (rash, or hives), less fatigue, malaise. The drug used in accordance with the recommendations did not affect psychomotor performance and ability to drive and use machines.

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Categories: Antifungal